MAPKAP Kinase 2 (MAPKAPK2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1:5000~1:10000 IF: 1:50~1:200
Reactivity	Human, Rat, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human MAPKAPK-2.
Specificity	MAPKAPK-2 (T334) polyclonal antibody detects endogenous levels of MAPKAPK-2 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 45 kDa
Gene Name	mitogen-activated protein kinase-activated protein kinase 2
Database Link	Entrez Gene 9261 Human UniProt ID P49137
Background	In response to cytokines, stress, and chemotactic factors, MAP kinase-activated protein kinase 2 (MAPKAPK-2) is rapidly phosphorylated and activated. It has been shown that MAPKAPK-2 is a direct target of p38 MAPK. Multiple residues of MAPKAPK-2 are phosphorylated in vivo in response to stress. However, only four residues (Thr25, Thr222, Ser272, and Thr334) are phosphorylated by p38 MAPK in an in vitro kinase assay. Phosphorylation at Thr222, Ser272, and Thr334 appears to be essential for the activity of MAPKAPK-2. Thr25 is phosphorylated by p42 MAPK in vitro, but is not required for the activation of MAPKAPK-2.
Synonyms	MAPK-activated protein kinase 2; MAPKAP-K2; MAPKAPK-2; MAPKAP kinase 2; MAP kinase-activated protein kinase 2; MK-2; MK2
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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