PER2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:2000~1:5000 IHC: 1:50~1:200
Reactivity	Human, Pig
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to Human PER2.
Specificity	PER2 polyclonal antibody detects endogenous levels of PER2 protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 155 kDa
Gene Name	period circadian clock 2
Database Link	Entrez Gene 8864 Human UniProt ID O15055
Background	Biological timepieces called circadian Clocks are responsible for the regulationof hormonal rhythms, sleep cycles and other behaviors. The superchiasmaticnucleus (SCN), which is located in the brain, was the first mammalian circadian Clock to be discovered. A number of transcription factors appearing to bemolecular components of the SCN Clock have been identified. Mutations within the Clock gene increase the length of the endogenous period and cause aloss of rhythmicity of circadian oscillations. Three mammalian period proteins, designated Per1, Per2 and Per3, exhibit circadian rhythyms in the SCN. Duringsubjective night, Per1 and Per2 RNA levels increase in response to light pulses while Per3 RNA levels show no change in response to light pulses. Tim, fortimeless, interacts with Per1 as well as Per2; and Tim and Per1 negativelyregulate Clock-BMAL1-induced transcription.
Synonyms	Circadian clock protein PERIOD 2; hPER2; KIAA0347; PER2; Period circadian protein homolog 2
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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