MEK1 (MAP2K1) Rabbit Polyclonal Antibody

CAT#: TA392531S

MEK1 (Phospho-S298) polyclonal antibody

Size: 25 ul 100 ul



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CNY 800.00


货期*
2周

规格
    • 25 ul

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经常一起买 (1)
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Specifications

Product Data
Applications IF, IHC, WB
Recommend Dilution WB: 1:1000~1:2000 IHC: 1:50~1:200 IF: 1:50~1:200
Reactivity Human, Rat, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic phosphopeptide derived from human MEK1 around the phosphorylation site of Serine 298.
Specificity MEK1 (Phospho-S298) polyclonal antibody detects endogenous levels of MEK1 protein only when phosphorylated at Ser298.
Formulation Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration 1mg/ml
Conjugation Unconjugated
Storage Condition Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size ~ 45 kDa
Gene Name mitogen-activated protein kinase kinase 1
Background MEK1 (Mitogen activated protein kinase kinase 1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1 activates ERK1 and ERK2 MAP kinases. Mitogen activated protein kinase kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.
Synonyms Dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAP2K1; MAPK/ERK kinase 1; MAP kinase kinase 1; MAPKK 1; MEK-1; MEK 1; MKK1; PRKMK1
Note For research use only, not for use in diagnostic procedure.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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