IFNGR1 Rabbit Polyclonal Antibody
CAT#: TA392420S
CD119 polyclonal antibody
Size: 100 ul
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CNY 800.00
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CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | WB: 1:1000~1:2000 |
Reactivity | Human, Rat, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant protein of human CD119. |
Specificity | CD119 polyclonal antibody detects endogenous levels of CD119 protein. |
Formulation | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2. |
Concentration | 1mg/ml |
Conjugation | Unconjugated |
Storage Condition | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
Predicted Protein Size | ~ 45-90 kDa |
Gene Name | interferon gamma receptor 1 |
Database Link | |
Background | Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation Associates with transmembrane accessory factor IFNGR2 to form a functional receptor.Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription.STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity). |
Synonyms | CD119; CDw119; IFN-gamma-R-alpha; IFN-gamma-R1; IFN-gamma receptor; Interferon gamma receptor 1; Interferon gamma receptor alpha-chain |
Note | For research use only, not for use in diagnostic procedure. |
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