GCSF Receptor (CSF3R) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:1000~1:2000
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human CD114/CSF3R.
Specificity	CD114/CSF3R polyclonal antibody detects endogenous levels of CD114/CSF3R protein.
Formulation	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Concentration	1mg/ml
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Predicted Protein Size	~ 105 kDa
Gene Name	colony stimulating factor 3 receptor
Database Link	Entrez Gene 1441 Human UniProt ID Q99062
Background	Granulocyte colony-stimulating factor receptor (G-CSF-R) is a transmembrane protein comprised of an immunoglobulin-like (Ig-like) domain, a cytokine receptor-homologous (CRH) domain, and three fibronectin type III (FN III) domains. G-CSF-R is expressed on all granulocytic lineages, including progenitor cells, and has been detected on monocytes, T and B lymphocytes, as well as non-hematopoietic tissues including cardiomyocytes and neural stem cells. The primary ligand for G-CSF-R is the cytokine granulocyte colony-stimulating factor (G-CSF). G-CSF-R has no intrinsic tyrosine kinase activity; ligand binding induces conformational changes in the receptor, leading to activation of the Jak/Stat, PI3K/Akt, and MAPK pathways. G-CSF induces differentiation and proliferation of myeloid progenitor cells into neutrophils. Multiple diseases have been associated with mutations of the G-CSF-R gene, CSF3R, including severe congenital neutropenia (SCN), chronic neutrophilic leukemia (CNL), and atypical chronic myeloid leukemia (aCML).
Synonyms	CD_antigen: CD114; CSF3R; G-CSF-R; G-CSF receptor; GCSFR; Granulocyte colony-stimulating factor receptor
Note	For research use only, not for use in diagnostic procedure.
Reference Data

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