Anti-PCSK9 antibody(DMC222), IgG1 Chimeric mAb

Specifications

Product Data
Applications	ELISA, FC
Recommend Dilution	ELISA 1:5000-10000 Flow Cyt 1:100
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Formulation	1XPBS
Concentration	Lot specific
Purification	Purified from cell culture supernatant by affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Background	This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Synonyms	FH3, FHCL3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9
Reference Data

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