STAT5A Mouse Antibody [Clone ID: M251]
CAT#: TA389218
Anti-Stat5 (C-terminal region) Antibody
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CNY 4,463.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | M251 |
Applications | ICC, WB |
Recommend Dilution | WB: 1:1000 ICC: 1:100 |
Reactivity | Human, Rat, Mouse |
Host | Mouse |
Immunogen | Clone (M251) was generated from a recombinant protein that included amino acid residues in the C-terminal region of human Stat5A. This sequence has high homology to the conserved regions in rat and mouse Stat5A and B. |
Specificity | The antibody detects a 92 kDa* band corresponding to Stat5A on SDS-PAGE immunoblots of human A431 cells. |
Formulation | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
Concentration | lot specific |
Purification | Protein A Purified |
Conjugation | Unconjugated |
Storage Condition | Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
Predicted Protein Size | 92 |
Database Link | |
Background | The stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Stat5 is activated in response to a wide variety of ligands including IL-2, GM-CSF, growth hormone, and prolactin. Phosphorylation at Tyr-694 is required for Stat5A activation. Stat5 has been found to be constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL-3, which suggests its involvement in angiogenesis and cell motility. Both Stat5A (Tyr-694) and Stat5B (Tyr-699) are independently regulated and activated in various cell types. For instance, both isoforms are activated in response to IFNα in B cells, but only Stat5A is phosphorylated in response to IFNα in HeLa cells. |
Note | Protein G purified tissue culture supernatant. |
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