EPHA2 Mouse Antibody [Clone ID: M088]

CAT#: TA389126

Anti-EphA2 (Extracellular region) M088 Antibody



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CNY 4,463.00


货期*
5周

规格
    • 100 ul

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Specifications

Product Data
Clone Name M088
Applications ICC, IP
Recommend Dilution ICC: 1:200
Reactivity Human
Host Mouse
Immunogen Clone (M088) was generated from a recombinant protein that included the extracellular region of human EphA2 protein.
Specificity Clone M088 mouse monoclonal antibody detects native human EphA2, as well as aldehyde-fixed EphA2. The antibody works for staining in immunocytochemistry, capture and detection in ELISA, and native immunoprecipitation assays.
Formulation PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Concentration lot specific
Purification Protein G Purified
Conjugation Unconjugated
Storage Condition Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Predicted Protein Size 125
Background The Eph family of receptor tyrosine kinases and their Ephrin ligands are important for cell positioning and morphogenesis during development. Eph receptors are classified into 10 EphA and 6 EphB receptors, which preferentially bind to the type A and type B ephrins, respectively. Ephrin type-A receptor 2 (EphA2), also known as epithelial cell kinase (Eck), binds the ephrin A1 (EFNA1) ligand, and has roles in neuronal development and repair, as well as carcinogenesis. EphA2 receptor has an N-terminal ligand-binding domain followed by a cysteine-rich domain with an epidermal growth factor-like motif and two fibronectin type-III repeats in the extracellular region, and a sterile alpha motif (SAM), and a PDZ domain-binding motif in the intracellular region. EphA2 is expressed in many types of cancers, including breast, colon, bladder, gastric, and glioblastoma. In bladder cancers, EphA2 may be activated by progranulin leading to phosphorylation at Ser-897 and bladder tumorigenesis. EphA2 may be an important therapeutic target and biomarker for several types of cancer.
Note Protein G purified tissue culture supernatant.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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