ATM Mouse Antibody [Clone ID: M361]
CAT#: TA389055
Anti-ATM (C-terminal region) Antibody
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CNY 3,413.00
货期*
5周
规格
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经常一起买 (1)
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Specifications
Product Data | |
Clone Name | M361 |
Applications | FC, ICC, IP, WB |
Recommend Dilution | WB: 1:1000 ICC: 1:100 |
Reactivity | Human |
Host | Mouse |
Immunogen | Clone M361 was generated from a recombinant sequence corresponding to amino acids in the C-terminal region of human ATM. |
Specificity | This antibody detects a 370 kDa* protein corresponding to the molecular mass of ATM on SDS-PAGE immunoblots of human A431 and Jurkat cells. |
Formulation | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
Concentration | lot specific |
Purification | Protein A Purified |
Conjugation | Unconjugated |
Storage Condition | Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
Predicted Protein Size | 370 |
Database Link | |
Background | Ataxia telangiectasia mutated kinase (ATM) is a serine/threonine kinase that regulates cell cycle checkpoints and DNA repair. Mutations of ATM cause a spectrum of defects ranging from neurodegeneration to cancer predisposition. Activation of ATM after DNA damage involves Cdk5 mediated phosphorylation of Ser-794 followed by autophosphorylation at Ser-1891. Active ATM kinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis and DNA repair. The Cdk5–ATM pathway regulates phosphorylation and function of the ATM targets p53 and H2AX in postmitotic neurons. Other known substrates of ATM include Chk2, Chk1, CtIP, 4E-BP1, BRCA1, RPA3, SMC1, FANCD2, Rad17, Artemis, Nbs1, and the I-2 regulatory subunit of PP1. Thus, activation of Cdk5 by DNA damage may be an important initiator of ATM-dependent regulation of cell cycle checkpoints. |
Note | Protein G purified tissue culture supernatant. |
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