Tgoln2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide from the C-terminus region of the rat TGN38/46 protein, conjugated to keyhole limpet hemocyanin (KLH).
Specificity	Specific for endogenous levels of the ~35 kDa TGN38 protein. Additionally, a ~97 kDa band representing glycosylated TGN38 protein may be seen in rodent species.
Formulation	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Concentration	lot specific
Purification	Antigen Affinity Purified from Pooled Serum
Conjugation	Unconjugated
Storage Condition	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Predicted Protein Size	35, 97
Gene Name	trans-golgi network protein 2
Database Link	Entrez Gene 192152 Rat UniProt ID P19814
Background	TGN38, also known as TGN46, is a type 1 integral membrane protein which predominantly localizes to the trans-Golgi network (TGN), and rapidly cycles to and from the cell surface. The cytosolic domain of TGN38/46 is involved in the reversible recruitment to the membrane with other cytosolic proteins for vesicle formation, while the luminal domain is involved in maintaining the morphology of the TGN (Banting, G., Ponnambalam, S., 1997). The cytosolic domain of TGN38/46 forms a complex with rab6, a small GTP-binding protein, and p62 where vesicle formation occurs at the exit sites of the TGN (Jones, S.M., et al, 1993). TGN38 is widely used as a reliable Golgi marker.
Synonyms	MGC14722; TGN38; TGN46; TGN48; TGN51; TTGN2
Note	Prepared from pooled rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
Reference Data

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