Nuclear stain of multiple gene products including Nup62, Nup133 Mouse Monoclonal Antibody [Clone ID: 39C7]

Specifications

Product Data
Clone Name	39C7
Applications	ICC
Recommend Dilution	ICC: 1:50-1:100 (mammalian cells) 1:100-1:500 (yeast cells)
Reactivity	Bovine, Chicken, Drosophila, Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Yeast nuclear preparations
Specificity	Specific for endogenous levels of the nuclear pore complex proteins.
Formulation	Concentrated tissue culture supernatent + 10 mM NaN3.
Concentration	lot specific
Purification	Concentrated tissue culture supernatant
Conjugation	Unconjugated
Storage Condition	Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
Background	The nuclear pore complex (NPC) is a very large structure made up of at least 50 different proteins that span the double membrane of the nuclear envelope functioning as a gateway for macromolecular traffic between the cytoplasm and the nucleus (Nakielny and Dreyfuss,1999). Discrete nuclear pore complex proteins or nucleoporins such as NUP98, NUP180 and p62 have been implicated in autoimmune disease and cancer. Patients with primary biliary cirrhosis (PBC) frequently produce autoantibodies against p62 and NUP180 (Wilken et al., 1993; Nesher et al., 2001) while NUP98 translocations have been found in patients with acute myelogenous leukemia (AML) (Jaju et al. 2001)
Note	Concentrated tissue culture supernatant.
Reference Data

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