VPS16 Rabbit Polyclonal Antibody

CAT#: TA388777

VPS16 Rabbit polyclonal antibody



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CNY 1,999.00

CNY 3,280.00


货期*
2周

规格
    • 100 ug

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Specifications

Product Data
Applications IHC, WB
Recommend Dilution Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200
Reactivity Rat, Human
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant Human VPS16 protein (7-89AA)
Formulation Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Concentration lot specific
Purification >95%, Protein G purified
Conjugation Unconjugated
Storage Condition Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Background Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for recruitment of VPS33A to the HOPS complex (PubMed:23901104). Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS33A but not VPS33B (PubMed:25783203). The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG (PubMed:24554770).
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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