CEACAM5 Rabbit Monoclonal Antibody [Clone ID: BW431/26]

Specifications

Product Data
Clone Name	BW431/26
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	The original antibody was generated by immunizing mice with CEA positive adenocarcinoma cells preferably from lungs.
Specificity	This antibody recognizes and binds human carcinoembryonic antigen in its purified state as well as on tissue sections. Technetium 99-labeled (Tc-99m) BW431/26 has been used in the diagnosis and detection of colorectal carcinomas, breast cancers, bladder carcinomas, lung adenocarcinomas and their recurrences by immunoscintigraphy (PMID: 2602902, 2662074, 2685692, 2297747, 2157833, 2166552, 2383485, 1984945 ). The use of Tc-99m-BW 431/26 immunoconjugates in immunoscintigraphy resulted in reduction of radiation dose for the patient down to 5% of the dose applied as compared with I-131 labelled MAbs (PMID: 3262953). Humanized version of this antibody also shows similar binding affinity as compared to its murine parent antibody (PMID: 1762576).
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	carcinoembryonic antigen related cell adhesion molecule 5
Database Link	Entrez Gene 1048 Human UniProt ID P06731
Synonyms	CD66e; CEA; DKFZp781M2392; OTTHUMP00000199034
Note	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG3 format, for improved compatibility with existing reagents, assays and techniques.
Reference Data

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