B7-1 (CD80) Rabbit Monoclonal Antibody [Clone ID: 16C10]

Specifications

Product Data
Clone Name	16C10
Applications	ELISA
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	This antibody was generated by immunization of cynomolgus monkeys with human B7.1 antigen.
Specificity	This antibody binds human CD80 and inhibits the B7.1:CD28 pathway. This antibody can be used for identification of human B7.1 antigen and is capable of inhibiting the binding of B7.1 to CD28, however it does not block the binding of B7.1 to CTLA-4. This antibody further inhibits the production of IL-2. Blocking of the primary activation signal between CD28 and B7.1 (CD80) with these antibodies while allowing the unimpaired or coincident interaction of CTLA-4 and B7.1 represents a combined antagonistic effect on positive co-stimulation with an agonistic effect on negative signaling. The binding of the antibody to soluble B7.1 was tested using ELISA. This antibody tested positive for binding to human C1q protein. This antibody is reported to cause keratinocyte hyperproliferation and decrease in psoriasis by inhibiting the B7:CD28 pathway. This antibody is further reported to be useful for the treatment of intestinal inflammation and rheumatoid arthritis.
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	CD80 molecule
Database Link	Entrez Gene 941 Human UniProt ID P33681
Synonyms	B7; BB1; CD28LG; CD28LG1; LAB7
Note	This chimeric rabbit antibody was made using the variable domain sequences of the original IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Reference Data

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