Ccr7 Rat Monoclonal Antibody [Clone ID: 4B12]

Specifications

Product Data
Clone Name	4B12
Applications	FC, FN, IP
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	This antibody was raised by immunizing rats with mouse CCR7 antigen.
Specificity	This antibody is specific to the mouse CCR7 protein, which was confirmed by immunoprecipitation (Ritter et al, 2004). This antibody was used for flow cytometry and the staining quality can be improved by incubation at 37°C (Britschgi et al, 2008). This antibody is widely used to monitor the activation of dendritic cells in mice (Ohl et al, 2004; Ritter et al, 2004; Zhao et al, 2019). It was also utilized in immunoprecipitation of the CCR7 receptor protein (Ritter et al, 2004). The antibody does not interfere with ligands binding to the CCR7 receptor, which was confirmed by a transmigration assay (Ritter et al, 2004). It does not interfere with T-cell migration (Ritter et al, 2004). The antibody also is not agonistic as it does not activate the receptor (Ritter et al, 2004).
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	chemokine (C-C motif) receptor 7
Database Link	Entrez Gene 12775 Mouse UniProt ID P47774
Synonyms	BLR2; CC-CKR-7; CCR-7; CD197; CDw197; CMKBR7; EBI1; EVI1
Reference Data

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