B7-1 (CD80) Rabbit Monoclonal Antibody [Clone ID: IDEC-114 (Galiximab)]
CAT#: TA386090
Recombinant Anti-CD80 (Clone IDEC-114 (Galiximab))
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CNY 6,881.00
货期*
6周
规格
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Specifications
Product Data | |
Clone Name | IDEC-114 (Galiximab) |
Applications | Bl, ELISA, FC, IHC, IP, WB |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal |
Immunogen | Galiximab was prepared by immunizing cynomolgus monkeys with recombinant CD80 antigen. The variable regions of the light and heavy chains were then cloned by being incorporated into a cassette vector (N5LG1) containing human constant region genes and subsequently transfected into the Dg44 CHO cell line (Hariharan K, 2013) |
Specificity | Galiximab is a primatized mAb which consists of human constant and primate (cynomolgus macaque) variable regions and binds specifically to CD80. CD80 is a surface glycoprotein and a member of the B7 family of costimulatory molecules. CD80 antigen regulates T cell activation (through interacting with CD28 or CD152) and is expressed transiently in antigen-presenting cells, T cells and normal B cells, and expressed consitutively on various subtypes of B-cell lymphomas. Galiximab acts to decrease in cell proliferation, inhibition of the constitutively active NF-κB pathway, increase in apoptosis and ADCC against various B-cell lymphoma cell lines. Galiximb affects CD28 and CD152 interactions with CD80. This antibody can also be used for FC, WB, ELISA, IP and IHC. |
Formulation | PBS with 0.02% Proclin 300. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles. |
Gene Name | CD80 molecule |
Database Link | |
Synonyms | B7; BB1; CD28LG; CD28LG1; LAB7 |
Note | This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
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