Galanin (GAL) Mouse Monoclonal Antibody [Clone ID: 4B3]

Specifications

Product Data
Clone Name	4B3
Applications	Bl, ELISA, ICC, WB
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	C-terminal fusions of KLH to human galanin,
Specificity	The antibody binds to galanin with an affinity constant (Kd) of 0.07 nM reported for the original antibody. The antibody binds specifically to galanin, a neuropeptide involved in many biological processes, including nociception, modulation and inhibition of action potentials, cognition, feeding, regulation of mood and blood pressure, smooth muscle contraction of the gastrointestinal (GI) tract and insulin release. Galanin acts on three G-protein coupled receptors, GALR1, GALR2 and GALR3, which are highly expressed in the brain, spinal cord and GI tract of humans and other mammals. Activation of the receptors has been reported to activate ATP-sensitive K+ channels, and inhibit voltage-gated Ca2+ channels. Galanin has been associated with the development of cancer, Alzheimer's disease, epilepsy, depression, eating disorders, diabetes and obesity. The monoclonal antibody 4B3 binds to the C-terminal region of Galanin, between residues 21 and 27, blocking its activity, and can be used clinically in the prevention and treatment of diseases mentioned.
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	galanin and GMAP prepropeptide
Database Link	Entrez Gene 51083 Human UniProt ID P22466
Synonyms	GAL1; galanin; GALN; GLNN; GMAP; MGC40167
Note	This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.