BACE2 Mouse Monoclonal Antibody [Clone ID: 1/ 9]

Specifications

Product Data
Clone Name	1/ 9
Applications	IHC, WB
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human BACE2 244–333.
Specificity	The antibody binds specifically to BACE2, an enzyme responsible for the proteolytic cleavage of amyloid precursor protein (APP). The protein is cleaved between residues 690 and 691, leading to the formation of beta-cleaved soluble APP and a C-terminal membrane bound fragment (CTFβ). The latter is then cleaved by gamma-secretase to generate amyloid beta peptide. BACE is the rate-limiting enzyme in the pathway, and is a potential target in the treatment of Alzheimer's Disease (AD),a neurodegenerative disorder characterised by amyloid beta plaques within the brain. The BACE2 protein is encoded in chromosome 21, in a region critical for the development of Down's Syndrome, and may play a role in the amyloid beta deposition in the disease.
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	beta-site APP-cleaving enzyme 2
Database Link	Entrez Gene 25825 Human UniProt ID Q9Y5Z0
Synonyms	AEPLC; ALP56; ASP1; ASP21; BAE2; CDA13; CEAP1; DRAP; Memapsin-1; Theta-secretase
Note	This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques.
Reference Data

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