CD40L (CD40LG) Mouse Monoclonal Antibody [Clone ID: hu5c8 (Ruplizumab)]

Specifications

Product Data
Clone Name	hu5c8 (Ruplizumab)
Applications	Bl, FC, WB
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human CD40L
Specificity	The antibody binds to CD40L with an IC50 of 0.845 ug/ml. The antibody binds specifically to CD40L, a surface receptor expressed on activated T cells which acts as a costimulatory molecule to trigger immune responses. The antibody neutralises CD40L function, as it blocks the interaction between CD40 and CD40L. When injected into cynomolgus monkeys, the original therapeutic antibody was found to have a T1/2 of 531  ± 155 hours.
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	CD40 ligand
Database Link	Entrez Gene 959 Human UniProt ID P29965
Synonyms	CD40-L; CD40L; CD154; gp39; hCD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP
Note	This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Reference Data

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