TrkA (NTRK1) Rabbit Monoclonal Antibody [Clone ID: MNAC13]

Specifications

Product Data
Clone Name	MNAC13
Applications	Bl, ELISA, IHC
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Human TrkA ECD.
Specificity	This antibody binds to the extracellular domain of TrkA. It was shown not to cross react with TrkB . Moreover MNAC13 is specific to TrkA with negligible reactivity to TrkB and TrkC. This antibody binds to human TrkA, a receptor tyrosine kinase involved in the development and the maturation of the CNS and the PNS through regulation of proliferation, differentiation, and survival of the sympathetic and nervous neurons. It is a receptor for NGF and phosphorylates several downstream proteins regulating a variety of signalling cascades. This antibody neutralizes the NGF-TrkA interation.
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	neurotrophic receptor tyrosine kinase 1
Database Link	Entrez Gene 4914 Human UniProt ID P04629
Synonyms	DKFZp781I14186; MTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA
Note	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Reference Data

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