Paxillin (PXN) Rabbit Monoclonal Antibody [Clone ID: LD2 sAB]

Specifications

Product Data
Clone Name	LD2 sAB
Applications	ELISA, WB
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Peptide corresponding to paxillin-LD2 motif (residues 141-156) fused to MBP; peptide sequence: NLSELDRLLLELNAVQHNP.
Specificity	The antibody binds specifically to the LD-2 motif of human paxillin with a Kd of 24 nM. This antibody binds to the LD2-motif of human paxillin, a signal transduction adaptor protein involved in focal adhesion, with binding partners including integrins, Src, FAK or actin complexes. The antibody inhibits complex formation between paxillin and FAK. Paxillin is involved in both inside-out cell signalling and outside-to-inside cell signalling.
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	paxillin
Database Link	Entrez Gene 5829 Human UniProt ID P49023
Synonyms	FLJ16691; paxillin
Note	This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.
Reference Data

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