Cd8a Rat Monoclonal Antibody [Clone ID: YTS 169.4]

Specifications

Product Data
Clone Name	YTS 169.4
Applications	FC, IHC
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Murine CD8 (lyt-2).
Specificity	Recognises the murine CD8 cell surface antigen expressed by a subset of T lymphocytes. The antibody has been shown to show depleting activity in vivo. Mice have two alleles for CD8, Lyt2.1 and Lyt2.2, which are restricted to certain mouse strains. Lyt2.1, for example, is expressed in the mouse strains CBA, AKR, C3H, and DBA, whereas Lyt2.2 is expressed in the mouse strains BALB/c and C57BL/6 (B/6). YTS 169.4 was originally raised against CBA mouse thymocytes, however there are studies using it in C57BL/6 and BALB/c mice. I has been used specifically as a as a pan-reactive Lyt2 reagent (Tavare et al., 2014; pmid: 24390540).
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	CD8 antigen, alpha chain
Database Link	Entrez Gene 12525 Mouse UniProt ID P01731
Synonyms	CD8; Leu2; MAL; OTTHUMP00000203721; p32
Note	This is a chimeric antibody created to reduce immunogenicity during in vivo applications.
Reference Data

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