Sumo 1 (SUMO1) Rabbit Monoclonal Antibody [Clone ID: R04-9G9]

Specifications

Product Data
Clone Name	R04-9G9
Applications	IHC, WB
Recommend Dilution	WB: 1/1000-1/5000 IHC: 1/20-1/100
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Sumo 1
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 12 kDa; Observed MW: _
Gene Name	small ubiquitin-like modifier 1
Database Link	Entrez Gene 7341 Human UniProt ID P63165
Background	Swiss-Prot Acc.P63165.Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).
Synonyms	DAP-1; GMP1; OFC10; PIC1; SENP2; Sentrin; SMT3; SMT3C; SMT3H3; SUMO-1; UBL1
Reference Data

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