SP1 Rabbit Monoclonal Antibody [Clone ID: R06-9I9]

Specifications

Product Data
Clone Name	R06-9I9
Applications	IF, IHC, IP, WB
Recommend Dilution	WB: 1/1000 IHC: 1/100 ICC/IF: 1/20 IP: 1/20
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant protein of human SP1
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 81 kDa; Observed MW: 90 kDa
Gene Name	Sp1 transcription factor
Database Link	Entrez Gene 6667 Human UniProt ID P08047
Background	Swiss-Prot Acc.P08047.Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.
Synonyms	TSFP1
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.