SNAP25 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IP, WB
Recommend Dilution	WB: 1/500-1/2000 ICC/IF: 1/50-1/200 IP: 1/50
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthesized peptide derived from human SNAP25
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	25kDa
Gene Name	synaptosome associated protein 25kDa
Database Link	Entrez Gene 6616 Human UniProt ID P60880
Background	Swiss-Prot Acc.P60880.SNAP25 forms a core complex with the SNARE proteins syntaxin and synaptobrevin to mediate synaptic vesicle fusion with the plasma membrane during Ca2+-dependent exocytosis. This complex is responsible for exocytosis of the neurotransmitter γ-aminobutyric acid (GABA). Neurotransmitter release is inhibited by proteolysis of SNAP25 by botulinum toxins A and E. SNAP25 plays a secondary role as a Q-SNARE involved in endosome fusion; the protein is associated with genetic susceptibility to attention-deficit hyperactivity disorder (ADHD).
Synonyms	bA416N4.2; dJ1068F16.2; FLJ23079; RIC-4; RIC4; SEC9; SNAP; SNAP-25; SUP
Reference Data

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