SMAD2 Rabbit Monoclonal Antibody [Clone ID: R03-3F8]

Specifications

Product Data
Clone Name	R03-3F8
Applications	IF, IHC, IP, WB
Recommend Dilution	WB: 1/1000-1/5000 IHC: 1/20 ICC/IF: 1/20-1/100 IP: 1/20
Reactivity	Human, Rat, Hamster
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Smad2
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 52 kDa; Observed MW: 52 kDa
Gene Name	SMAD family member 2
Database Link	Entrez Gene 4087 Human UniProt ID Q15796
Background	Swiss-Prot Acc.Q15796.Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Synonyms	hMAD-2; hSMAD2; JV18; JV18-1; MADH2; MADR2; MGC22139; MGC34440
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.