Semaphorin 4D (SEMA4D) Rabbit Monoclonal Antibody [Clone ID: R05-2E3]

Specifications

Product Data
Clone Name	R05-2E3
Applications	IF, WB
Recommend Dilution	WB: 1/1000-1/5000 ICC/IF: 1/20-1/100
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Semaphorin 4D
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 96 kDa; Observed MW: 120 kDa
Gene Name	semaphorin 4D
Database Link	Entrez Gene 10507 Human UniProt ID Q92854
Background	Swiss-Prot Acc.Q92854.Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.
Synonyms	A8; BB18; C9orf164; CD100; coll-4; FLJ33485; FLJ34282; FLJ39737; FLJ46484; GR3; M-sema-G; MGC169138; MGC169141; OTTHUMP00000021622; OTTHUMP00000208950; OTTHUMP00000208951; OTTHUMP00000208957; SEMAJ
Reference Data

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