Proteasome subunit alpha type 6 (PSMA6) Rabbit Monoclonal Antibody [Clone ID: R01-4I2]

Specifications

Product Data
Clone Name	R01-4I2
Applications	IF, WB
Recommend Dilution	WB: 1/2000-1/10000 ICC/IF: 1/50-1/100
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Proteasome subunit alpha type 6
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 27 kDa; Observed MW: 27 kDa
Gene Name	proteasome subunit alpha 6
Database Link	Entrez Gene 5687 Human UniProt ID P60900
Background	Swiss-Prot Acc.P60900.Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Synonyms	IOTA; MGC2333; MGC22756; MGC23846; p27K; PROS-27; PROS27
Reference Data

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