Prion protein PrP (PRNP) Rabbit Monoclonal Antibody [Clone ID: R03-2E2]

CAT#: TA385060S

Prion Protein Rabbit monoclonal Antibody

Size: 20 ul 100 ul



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CNY 800.00


货期*
2周

规格
    • 20 ul

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Specifications

Product Data
Clone Name R03-2E2
Applications IHC, WB
Recommend Dilution WB: 1/1000-1/5000
IHC: 1/20
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Immunogen A synthetic peptide of human Prion protein PrP
Formulation 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration lot specific
Purification Affinity Purified
Conjugation Unconjugated
Storage Condition Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size Calculated MW: 28 kDa; Observed MW: 28 kDa
Gene Name prion protein
Background Swiss-Prot Acc.P04156.Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) . Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains .
Synonyms AA960666; AI325101; CD230; Prn; Prn-i; Prn-p; PrP; prP27-30; prP33-35C; PrP; PrPC; PrPSc; Sinc
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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