LIMS1 Mouse Monoclonal Antibody [Clone ID: 3C12-F7-A8]

Specifications

Product Data
Clone Name	3C12-F7-A8
Applications	FC, IF, IP, WB
Recommend Dilution	WB: 1/500-1/2000 ICC: 1/200-1/1000 FC: 1/200-1/400
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human PINCH expressed in E. Coli.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
Concentration	lot specific
Purification	Ascitic Fluid
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	37kDa
Gene Name	LIM zinc finger domain containing 1
Database Link	Entrez Gene 3987 Human UniProt ID P48059
Background	Swiss-Prot Acc.P48059.The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms	OTTHUMP00000161608; PINCH; PINCH-1; PINCH1
Reference Data

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