MAP1LC3A Mouse Monoclonal Antibody [Clone ID: 3E9-E5-C9]

Specifications

Product Data
Clone Name	3E9-E5-C9
Applications	WB
Recommend Dilution	WB: 1/1000
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide corresponding to human LC3B protein
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	14/16kDa
Gene Name	microtubule associated protein 1 light chain 3 alpha
Database Link	Entrez Gene 84557 Human UniProt ID Q9H492
Background	Swiss-Prot Acc.Q9H492,Q9GZQ8.Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.
Synonyms	LC3; LC3A; MAP1ALC3; MAP1BLC3; OTTHUMP00000030698
Reference Data

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