HRH3 Rabbit Monoclonal Antibody [Clone ID: R04-3I4]

Specifications

Product Data
Clone Name	R04-3I4
Applications	WB
Recommend Dilution	WB: 1/1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human HRH3/Histamine 3 Receptor
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 49 kDa; Observed MW: 49 kDa
Gene Name	histamine receptor H3
Database Link	Entrez Gene 11255 Human UniProt ID Q9Y5N1
Background	Swiss-Prot Acc.Q9Y5N1.The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization.MiscellaneousDoes not bind to cimetidine and tripolidine. Shows modest affinity for thioperamide, imetit, N-alpha-methylhistamine and R--alpha-methylhistamine. Isoform 4 is unable to bind to iodoproxyfan while isoforms 1 and 3 bind it with high affinity.
Synonyms	GPCR97; HH3R
Reference Data

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