HLTF Rabbit Monoclonal Antibody [Clone ID: R03-1E4]

Specifications

Product Data
Clone Name	R03-1E4
Applications	IF, WB
Recommend Dilution	WB: 1/2000-1/10000 ICC/IF: 1/20
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human HLTF
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 114 kDa; Observed MW: 114 kDa
Gene Name	helicase-like transcription factor
Database Link	Entrez Gene 6596 Human UniProt ID Q14527
Background	Swiss-Prot Acc.Q14527.Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters . These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
Synonyms	HIP116; HIP116A; HLTF1; RNF80; SMARCA3; SNF2L3; ZBU1
Reference Data

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