H2BC19P Rabbit Monoclonal Antibody [Clone ID: R05-1J4]

Specifications

Product Data
Clone Name	R05-1J4
Applications	IHC, IP, WB
Recommend Dilution	WB: 1/1000 IHC: 1/20 IP: 1/20
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Histone H2B
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 14 kDa; Observed MW: 14 kDa
Gene Name	histone cluster 2, H2bd (pseudogene)
Database Link	Entrez Gene 337874 Human UniProt ID O60814
Background	Swiss-Prot Acc.O60814.Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Synonyms	HIST2H2BD
Reference Data

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