Fadd Rabbit Monoclonal Antibody [Clone ID: R05-1K1]

Specifications

Product Data
Clone Name	R05-1K1
Applications	IHC, WB
Recommend Dilution	WB: 1/1000-1/5000 IHC: 1/20-1/50
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of mouse FADD
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 23 kDa; Observed MW: 28 kDa
Gene Name	Fas (TNFRSF6)-associated via death domain
Database Link	Entrez Gene 14082 Mouse UniProt ID Q61160
Background	Swiss-Prot Acc.Q61160.Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis . Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling .
Synonyms	GIG3; MGC8528; MORT1
Reference Data

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