CDK5RAP3 Rabbit Monoclonal Antibody [Clone ID: R07-1A1]

Specifications

Product Data
Clone Name	R07-1A1
Applications	IHC, IP, WB
Recommend Dilution	WB: 1/1000 IHC: 1/20 IP: 1/20
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human CDK5RAP3
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 57 kDa; Observed MW: 70 kDa
Gene Name	CDK5 regulatory subunit associated protein 3
Database Link	Entrez Gene 80279 Human UniProt ID Q96JB5
Background	Swiss-Prot Acc.Q96JB5.Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).
Synonyms	C53; FLJ13660; HSF-27; IC53; LZAP; MST016; OK/SW-cl.114
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.