CD3G Rabbit Monoclonal Antibody [Clone ID: R07-1C8]

Specifications

Product Data
Clone Name	R07-1C8
Applications	IHC, IP, WB
Recommend Dilution	WB: 1/2000-1/10000 IHC: 1/50-1/200 IP: 1/20-1/50
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human CD3G
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 21 kDa; Observed MW: 21 kDa
Gene Name	CD3g molecule
Database Link	Entrez Gene 917 Human UniProt ID P09693
Background	Swiss-Prot Acc.P09693.Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769). Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G.
Synonyms	CD3-GAMMA; FLJ17620; FLJ17664; FLJ79544; FLJ94613; MGC138597; T3G
Reference Data

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