Caspase 8 (CASP8) Mouse Monoclonal Antibody [Clone ID: 4C2-3G4-5G7]

CAT#: TA383881S

Caspase 8 (2G12) Mouse monoclonal Antibody

Size: 20 ul 100 ul



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CNY 800.00


货期*
2周

规格
    • 20 ul

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beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

CNY 300.00
CNY 1,430.00

Specifications

Product Data
Clone Name 4C2-3G4-5G7
Applications IF, IHC, WB
Recommend Dilution WB: 1/1000-2000
IHC: 1/200-500
ICC: 1/200
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Immunogen Recombinant Protein of Caspase-8
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.03% Proclin 300, pH 7.3.
Concentration lot specific
Purification Affinity Purified
Conjugation Unconjugated
Storage Condition Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size Observed MW (kDa):43,57
Gene Name caspase 8
Background Swiss-Prot Acc.Q14790.Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Synonyms ALPS2B; CAP4; Casp-8; FLICE; FLJ17672; MACH; MCH5; MGC78473; OTTHUMP00000163720
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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