Caldesmon (CALD1) Rabbit Monoclonal Antibody [Clone ID: R05-3D2]

Specifications

Product Data
Clone Name	R05-3D2
Applications	IHC, IP, WB
Recommend Dilution	WB: 1/2000-1/10000 IHC: 1/20 IP: 1/20
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Caldesmon
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 93 kDa; Observed MW: 70-80 kDa
Gene Name	caldesmon 1
Database Link	Entrez Gene 800 Human UniProt ID Q05682
Background	Swiss-Prot Acc.Q05682.Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration .
Synonyms	CAD; CDM; H-CAD; HCAD; L-CAD; LCAD; MGC21352; NAG22; OTTHUMP00000207949; OTTHUMP00000207954
Reference Data

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