CTIP2 (BCL11B) Rabbit Monoclonal Antibody [Clone ID: R08-5K7]

Specifications

Product Data
Clone Name	R08-5K7
Applications	WB
Recommend Dilution	WB: 1/2000-1/10000
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	A synthetic peptide of human Ctip2
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 96 kDa; Observed MW: 120-130 kDa
Gene Name	B-cell CLL/lymphoma 11B
Database Link	Entrez Gene 64919 Human UniProt ID Q9C0K0
Background	Swiss-Prot Acc.Q9C0K0.Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4+ T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element . May also function in the P53-signaling pathway .
Synonyms	CTIP-2; CTIP2; hRit1; hRIT1-alpha; RIT1
Reference Data

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