ATG4C Rabbit Monoclonal Antibody [Clone ID: R08-8G9]

Specifications

Product Data
Clone Name	R08-8G9
Applications	IHC, WB
Recommend Dilution	WB: 1/1000 IHC: 1/50
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant protein of human ATG4C
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 53 kDa; Observed MW: 53 kDa
Gene Name	autophagy related 4C cysteine peptidase
Database Link	Entrez Gene 84938 Human UniProt ID Q96DT6
Background	Swiss-Prot Acc.Q96DT6.Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation . Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Synonyms	APG4-C; APG4C; AUTL1; AUTL3; autophagin-3; FLJ14867
Reference Data

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