ATG16L1 Rabbit Monoclonal Antibody [Clone ID: R03-4G8]

Specifications

Product Data
Clone Name	R03-4G8
Applications	WB
Recommend Dilution	WB: 1/1000-1/2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant protein of human ATG16L1
Formulation	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration	lot specific
Purification	Affinity Purified
Conjugation	Unconjugated
Storage Condition	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Predicted Protein Size	Calculated MW: 68 kDa; Observed MW: 68 kDa
Gene Name	autophagy related 16 like 1
Database Link	Entrez Gene 55054 Human UniProt ID Q676U5
Background	Swiss-Prot Acc.Q676U5.Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).
Synonyms	APG16L; ATG16L; FLJ00045; FLJ10035; FLJ10828; FLJ22677; IBD10; WDR30
Reference Data

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