Phospholipase C gamma 1 (PLCG1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB,1:500 - 1:2000 IHC,1:10 - 1:100
Reactivity	Human, Mouse, Rat
Modifications	Phospho S1248
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic phosphorylated peptide around S1248 of human PLC gamma 1 (PLCG1) (NP_002651.2).
Formulation	Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size	148kDa
Gene Name	phospholipase C gamma 1
Database Link	Entrez Gene 5335 Human UniProt ID P19174
Background	The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms	1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; inositoltrisphosphohydrolase; NCKAP3; OTTHUMP00000178982; PLC-148; PLC-gamma-1; PLC-II; PLC1; PLC148; PLCgamma1
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.