Glucocorticoid Receptor (NR3C1) Rabbit Polyclonal Antibody

CAT#: TA379297

Glucocorticoid Receptor Rabbit polyclonal Antibody



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CNY 1,999.00

CNY 3,280.00


货期*
2周

规格
    • 100 ul

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经常一起买 (1)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
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Specifications

Product Data
Applications ICC/IF, IHC, WB
Recommend Dilution WB,1:500 - 1:2000
IF,1:50 - 1:200
Reactivity Human, Mouse
Modifications Unmodified
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human Glucocorticoid Receptor (NP_001191194.1).
Formulation Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Condition Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size 49-85kDa
Gene Name nuclear receptor subfamily 3 group C member 1
Background This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
Synonyms GCCR; GCR; GR; GRL
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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