NEDD4 2 (NEDD4L) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB,1:500 - 1:2000
Reactivity	Human, Mouse, Rat
Modifications	Phospho S448
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic phosphorylated peptide around S448 of human NEDD4L (NP_001138439.1).
Formulation	Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size	96-111kDa
Gene Name	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Database Link	Entrez Gene 23327 Human UniProt ID Q96PU5
Background	This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms	FLJ33870; hNedd4-2; KIAA0439; NEDD4-2; NEDD4.2; NEDL3; RSP5
Reference Data

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