LAMTOR1 Rabbit Polyclonal Antibody
CAT#: TA377950
LAMTOR1 Rabbit polyclonal Antibody
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CNY 1,999.00
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货期*
2周
规格
经常一起买 (1)
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Specifications
Product Data | |
Applications | ICC/IF, WB |
Recommend Dilution | WB,1:500 - 1:1000 IHC,1:50 - 1:100 IF,1:50 - 1:100 |
Reactivity | Human, Mouse, Rat |
Modifications | Unmodified |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-161 of human LAMTOR1 (NP_060377.1). |
Formulation | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 17kDa |
Gene Name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 |
Database Link | |
Background | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. |
Synonyms | 2400001E08Rik; p18; Pdro |
Reference Data |
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