Caspase 1 (CASP1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB,1:500 - 1:2000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human Caspase-1.
Formulation	Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size	10kDa/29kDa/35kDa/42kDa/45kDa
Gene Name	caspase 1
Database Link	Entrez Gene 834 Human UniProt ID P29466
Background	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Synonyms	CASP-1; caspase-1; ICE; IL-1BC; IL1B-convertase; IL1BC; IL1BCE; p45
Reference Data

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