Apc5 (ANAPC5) Rabbit Polyclonal Antibody
CAT#: TA373504
ANAPC5 Rabbit polyclonal Antibody
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CNY 2,700.00
货期*
2周
规格
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Specifications
Product Data | |
Applications | IHC, IP, WB |
Recommend Dilution | WB,1:500 - 1:2000 IHC,1:50 - 1:200 IP,1:50 - 1:100 |
Reactivity | Human, Mouse, Rat |
Modifications | Unmodified |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ANAPC5 (NP_057321.2). |
Formulation | Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20℃. Avoid freeze / thaw cycles. |
Predicted Protein Size | 25kDa/72kDa/85kDa |
Gene Name | anaphase promoting complex subunit 5 |
Database Link | |
Background | This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. |
Synonyms | APC5 |
Reference Data |
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