ATP citrate lyase (ACLY) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, IP, WB
Recommend Dilution	WB,1:500 - 1:2000 IHC,1:50 - 1:100 IP,1:50 - 1:100
Reactivity	Mouse
Modifications	Phospho S455
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic phosphorylated peptide around S455 of human ACLY (NP_001087.2).
Formulation	PBS with 0.05% proclin300,50% glycerol,pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size	91kDa/119kDa/120kDa
Gene Name	ATP citrate lyase
Database Link	UniProt ID P53396
Background	ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms	ACL; ATPCL; CLATP; OTTHUMP00000164773
Reference Data

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