PRTFDC1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Human Ovarian cancer ( granulosa cell tumor )tissue，Human testis tissue IHC: 25-100 Positive control: Human lung cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C.
Predicted Protein Size	26 kDa
Gene Name	phosphoribosyl transferase domain containing 1
Database Link	Entrez Gene 56952 Human UniProt ID Q9NRG1
Background	PRTFDC1 (phosphoribosyltransferase domain-containing protein 1), also known as HHGP, is a 225 amino acid protein that belongs to the purine/pyrimidine phosphoribosyltransferase family.The functions of PRTFCD1 are not well understood; however it has been suggested that it is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation. Conserved in vertebrates, PRTFDC1 is suggested to be a possible tumor-suppressor. PRTFDC1 is encoded by a gene which maps to chromosome 10. Spanning nearly 135 million base pairs, chromosome 10 makes up approximately 4.5% of the total DNA in cells and encodes nearly 1,200 genes. Three isoforms of PRTFDC1 exist due to alternative splicing events. Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). Is not expected to contribute to purine metabolism or GMP salvage.
Synonyms	FLJ11888; HHGP
Reference Data

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